Selective publications:

Closing the structure to function gap for LRRK2. Tokars V, Chen C, Parisiadou L. Trends in Biochemical Sciences. 2022, 47(3):187-188

Pathway-specific deregulation of striatal excitatory synapses in LRRK2 mutations. Chen C, Soto N, Kang S, Kozorovitskiy Y, Parisiadou L. eLife, 2020 Oct 2;9:e58997. doi: 10.7554/eLife.58997.

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. Liu G, Sgobio C, Gu X, Sun L, Lin X, Yu J, Parisiadou L, Xie C, Sastry N, Ding J, Lohr KM, Miller GW, Mateo Y, Lovinger DM, Cai H. Hum Mol Genet. 2015 Sep 15;24(18):5299-312. doi: 10.1093/hmg/ddv249. PubMed. PDF. 

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. Cho HJ, Yu J, Xie C, Rudrabhatla P, Chen X, Wu J, Parisiadou L, Liu G, Sun L, Ma B, Ding J, Liu Z, Cai H. EMBO J. 2014 Oct 16;33(20):2314-31. doi: 10.15252/embj.201487807. PubMed. PDF.

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Luo J, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H. Hum Mol Genet. 2014 Dec 15;23(24):6567-74. doi: 10.1093/hmg/ddu377. PubMed. PDF.

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Parisiadou L#, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H#. Nat Neurosci. 2014 Mar;17(3):367-76. doi: 10.1038/nn.3636. Recommended by F1000.  PubMed. PDF. 

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, Shen Y, Cai H. Hum Mol Genet. 2013 Feb 1;22(3):608-20. doi: 10.1093/hmg/dds470. PubMed. PDF.

Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1. Lin X*, Parisiadou L*, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, Cai H. J Neurosci. 2012 Jul 4;32(27):9248-64. doi: 10.1523/JNEUROSCI.1731-12.2012.Recommended by F1000. PubMed. PDF.

LRRK2 function on actin and microtubule dynamics in Parkinson disease. Parisiadou L, Cai H. Commun Integr Biol. 2010 Sep;3(5):396-400. doi: 10.4161/cib.3.5.12286. PubMed. PDF.

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Lin X*, Parisiadou L*, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H. Neuron. 2009 Dec 24;64(6):807-27. doi: 10.1016/j.neuron.2009.11.006. Recommended by F1000. PubMed. PDF.

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H. J Neurosci. 2009 Nov 4;29(44):13971-80. doi: 10.1523/JNEUROSCI.3799-09.2009. PubMed. PDF.

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